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October 19, 2016

News from the ESC 2016

We report the anticoagulation highlights from this key event in the cardiology calendar – the European Society of Cardiology (ESC) Congress – in this special edition of Arrhythmia Watch. Taking place in Rome, Italy, from 27th -31st August 2016, it attracted over 33,000 delegates from across the globe, including His Holiness Pope Francis. Studies selected for the much anticipated Hotline sessions included the ENSURE AF study looking at the use of edoxaban in cardioversion and the ANNEXA-4 study for reversal of acute bleeding.

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October 19, 2016

More real world data for OAC therapy

There are many challenges for physicians in managing patients with atrial fibrillation (AF). This has led to increasing interest in registry data giving insights into the real-world use of oral anticoagulation in non-valvular AF (NVAF). Below we highlight some of the registry data presented at this year’s congress

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October 19, 2016

UK patients not receiving anticoagulants properly

While oral anticoagulation (OAC) is recommended for the majority of patients with atrial fibrillation (AF) and ≥1 risk factor for stroke, OACs are not being prescribed for UK patients as per guidelines. This was the finding from a retrospective analysis of 105,000 patients enrolled into an observational community-based registry of 11 general practices (GP) serving the town of Darlington, England.

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October 19, 2016

Special groups: diabetes

Data from the PREFER in AF patient registry has shown that patients with atrial fibrillation (AF) and diabetes on insulin treatment are at a significantly increased risk of stroke/systemic embolism compared to both AF patients without diabetes and AF patients with diabetes but not on insulin treatment.1

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October 19, 2016

Special groups: gender

The PREFER in AF registry has also shown that women experience a greater burden of symptoms compared to men and that treatment with oral anticoagulation is similar in both genders.1

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October 19, 2016

Special groups: body mass index

Analysis of the ENGAGE AF –TIMI study has shown that obese patients with atrial fibrillation (AF) had a lower risk of stroke/systemic embolic events (SEE) and better survival than AF patients with a normal body mass index (BMI), but the risk of bleeding was higher in patients with a BMI ≥ 25.1

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October 19, 2016

Stopping oral anticoagulation increases stroke risk

Oral anticoagulation (OAC) is highly effective in reducing thromboembolism and mortality in atrial fibrillation (AF) and stopping OAC significantly increases risk of stroke and mortality. This is the principal finding from a study conducted by Dr Jose Miguel Rivera-Caravaca (Hospital Universitario Virgen de la Arrixaca, Murcia, Spain) and co-workers.1

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October 19, 2016

ENSURE AF: edoxaban allows prompt cardioversion in AF

Patients with atrial fibrillation (AF) who need anticoagulation before undergoing cardioversion may benefit from treatment with the non-vitamin K antagonist oral anticoagulant (NOAC), edoxaban, compared to best possible conventional therapy (warfarin and enoxaparin), according to results from the ENSURE-AF study presented during a hotline session at the meeting.

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October 19, 2016

Commentary on ENSURE-AF

British Junior Cardiologists Association (BJCA) President, Dr Jubin Joseph, who is also British Heart Foundation Clinical Research Fellow, at St Thomas’ Hospital, London, discussed ENSURE AF in our podcast (click here to view).

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October 19, 2016

ANNEXA 4: reversal agent shows efficacy in acute bleeding

Preliminary results in the ongoing ANNEXA-4 study have shown that andexanet can rapidly reverse anti-factor Xa activity in acutely bleeding patients and is associated with excellent or good haemostasis in most.

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  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

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