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Uninterrupted anticoagulation in cardiac ablation and implantation

Uninterrupted anticoagulation with vitamin K antagonists during ablation and device implantation is recommended in a position paper from the European Heart Rhythm Association, published recently in EP Europace.1

The recommendations are an update of European Heart Rhythm Association’s (EHRA) 2008 consensus document.2 Dramatic changes in the field during the last five years demanded a revision. There has been a steep rise in device implantation and even greater increases in ablation procedures, mainly pulmonary vein isolation. Since 2008 new drugs have been introduced, namely the non-vitamin K antagonist oral anticoagulants (also called new oral anticoagulants or NOACs) and the antiplatelets prasugrel and ticagrelor.

Three main topics are covered:

  • antithrombotic management in patients undergoing ablation for various conditions such as atrial fibrillation
  • antithrombotic management for the implantation or exchange of cardiac implantable electronic devices (CIEDs) including pacemakers, implantable cardioverter defibrillators (ICDs) and cardiac resynchonisation therapy (CRT) systems
  • peri-interventional bleeding complications on concurrent antiplatelet therapy.
Sticherling

Professor Christian Sticherling (University Hospital of Basel, Switzerland)

Recommendations on NOACs are given for the first time. The authors acknowledge that the field of NOACs and device implantation is rapidly evolving. They state: “Whether it is better to operate without interrupting these new agents or with temporary cessation is currently unclear, and more data are required.”

Professor Christian Sticherling (University Hospital of Basel, Switzerland), chair of the writing group, said: “Traditionally we interrupted anticoagulation during device implantation and restarted it afterwards. And we bridged with heparin around the time of the operation. The new recommendation is to continue to give the vitamin K antagonist and perform the operation without any bridging. That shows the lowest rate of perioperative bleeding.”

He added: “Also new is the recommendation not to interrupt vitamin K antagonists during ablation and particularly during pulmonary vein isolation which is the most common type of ablation nowadays.”

“We now have a whole range of new possibilities to combine anticoagulation with platelet inhibition,” Professor Sticherling continued. “At the same time we perform more invasive electrophysiology procedures in which most patients are on anticoagulation. This combination meant an update was needed to help physicians achieve the dual aims of avoiding thromboembolic events and minimising the risk of bleeding.”

The document recommends interruption of NOACs for device surgery, without heparin bridging. This advice is consistent with the EHRA Practical Guide on the use of NOACs in patients with non-valvular atrial fibrillation. The period of discontinuation should be based on individual product monographs, and the drug restarted 24 to 48 hours after surgery. “One of the key messages is that there is no heparin bridging because this causes bleeding complications,” said Professor Sticherling.

The document also recommends interrupting NOACs during ablation with pulmonary vein isolation, with the last dose given 24 hours before in patients with normal renal function. “We gathered the recent evidence to make our recommendations but new studies are on the way,” said Professor Sticherling. “I can almost predict that within a year we will have enough proof to recommend uninterrupted NOACs during ablation.”

The most controversial topic was the use of transoesophageal echocardiography (TEE) to screen for thrombi prior to ablation to prevent strokes. “Virtually all Europeans do TEE before ablation even if the stroke risk is low or the patient presents in sinus rhythm,” said Professor Sticherling. “The Americans have a higher threshold for performing TEE and this generated a lot of debate. We came to a consensus on when TEE should be used, and when it could be considered.”

He concluded: “This is a practical document which gives new advice on vitamin K antagonists and the first recommendations on NOACs. The aim of the recommendations is to avoid all thromboembolic complications while minimising bleeding.”

Wong

Dr Tom Wong (Royal Brompton Hospital, London)

Speaking to BJC Arrhythmia Watch, Dr Tom Wong (Royal Brompton Hospital, London) gave a UK interventionist’s perspective: “We welcome the ESC’s latest recommendation related to the use of uninterrupted vitamin K antagonist during ablation and device implantation.”

“Many centres in UK like ours at the Royal Brompton and Harefield had adopted this practice over the past years, based on the accumulating evidence in favour of this practice from a safety standpoint. The formal recommendation from ESC is tremendously helpful for achieving wider adoption of such practice,” Dr Wong added.

References

1. Sticherling C, Marin F, Birnie D, et al. Antithrombotic management in patients undergoing electrophysiological procedures: an European Heart Rhythm Association (EHRA) position document endorsed by the ESC Working Group Thrombosis, Heart Rhythm Society (HRS), and Asia Pacific Heart Rhythm Society (APHRS). Europace 2015. http://dx.doi.org/10.1093/europace/euv190

2. Consensus document on antithrombotic therapy in the setting of electrophysiological procedures. Europace 2008;10:513–27. http://dx.doi.org/10.1093/europace/eun104

Published on: June 26, 2015

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  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

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