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Clinical Articles, News & Views

Health and cost benefits from using a polypill

The use of a fixed-dose combination polypill to prevent recurring myocardial infarction can avoid up to 15% more fatal and non-fatal cardiovascular (CV) events, conferring potential savings to healthcare systems, according to a study published recently in the British Medical Journal.1

The study, which was conducted from a UK perspective, used a Markov model to predict the outcomes of a patient population using the polypill intervention (100 mg aspirin, 20 mg atorvastatin and 2.5, 5, or 10 mg ramipril). The patient population was selected to represent a risk profile typical of patients found in the UK and Western European countries – 72% male, mean age of 64.7 years and with a previous diagnosis of myocardial infarction. Model equations were used to determine the rates at which CV events occur as a function of baseline risks and therefore the likely effects of the person taking a polypill for a period of up to 10 years.

Cost-effectiveness assessments were made using known health economic modelling techniques to demonstrate that the 20% increase in adherence using a polypill intervention could lead to a significant reduction in deaths and non-fatal CV events – 47 per 1,000 patient population – over a 10-year period in the model examined, and a significant reduction in costs to healthcare systems.


1. Becerra V, Gracia A, Desai K et al. Cost-effectiveness and public health benefit of secondary cardiovascular disease prevention from improved adherence using a polypill in the UK. BMJ Open 2015;5.

Published on: June 26, 2015

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  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association

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