Please login or register to print this page.

Clinical Articles, News & Views

Atrial fibrillation: effects beyond the atrium?

Potential mechanisms behind the effects of atrial fibrillation (AF) on the ventricular myocardium – including diffuse ventricular fibrosis, focal myocardial scarring, and impaired myocardial perfusion and perfusion reserve – are explored in a review published recently in Cardiovascular Research.1

Authors explore the complex relationship between AF, systemic inflammation, and endothelial/microvascular dysfunction, as well as the effects of AF on ventricular calcium handling and oxidative stress. Finally, consideration is given to the clinical implications of these observations and concepts, with particular reference to rate vs. rhythm control.

AF is the most common sustained clinical arrhythmia and is associated with significant morbidity, mostly secondary to heart failure and stroke, and an estimated two-fold increase in premature death. Efforts to increase our understanding of AF and its complications have focused on unravelling the mechanisms of electrical and structural remodelling of the atrial myocardium, the authors say.

Yet, it is increasingly recognised that AF is more than an atrial disease, being associated with systemic inflammation, endothelial dysfunction, and adverse effects on the structure and function of the left ventricular myocardium that may be prognostically important, they conclude.

References

1. Wijesurendra RS, Casadei B. Atrial fibrillation: effects beyond the atrium?  Cardiovasc Res 2015;105:238–47. http://dx.doi.org/10.1093/cvr/cvv001

Published on: April 29, 2015

Members Area

Log in or Register now.

SEARCH THE SITE

RSS FEED

Subscribe to our RSS feed
home

GET EXCLUSIVE UPDATES

Sign up for our regular email newsletters & be the first to know about fresh articles and site updates.

RECENT COMMENTS

    None Found

ENDORSED BY

  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

You are not logged in

You need to be a member to print this page.
Sign up for free membership, or log in.

You are not logged in

You need to be a member to download PDF's.
Sign up for free membership, or log in.