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National Institute for Health and Care Excellence

Clinical Articles, News & Views

Apixaban recommended for treating and preventing DVT

Apixaban has been recommended as an option for treating and preventing venous thromboembolism (VTE) in adults in draft guidance1 published recently by the National Institute for Health and Care Excellence (NICE)

The Appraisal Committee concluded that apixaban could be considered a clinically and cost-effective use of NHS resources and recommended apixaban, within its marketing authorisation.

Commenting on the draft guidance, Professor Carole Longson, NICE Health Technology Evaluation Centre Director, said: “For many people, using warfarin can be difficult because of the need for frequent tests to see if the blood is clotting properly, and having to adjust the dose of the drug if it is not. Apixaban, like the other newer oral anticoagulants already recommended by NICE for the treatment and secondary prevention of VTE, does not require frequent blood tests to monitor treatment and so represents a potential benefit for many people who have had a VTE.”

“The Committee also heard that apixaban is the only oral anticoagulant for which the licensed dose is lower for secondary prevention than for initial treatment of VTE. This could also be of potential benefit in terms of reducing the risk of bleeding where treatment is continued and therefore increase the chance that a person would take apixaban long term,” Professor Longson added.

The draft guidance is now with consultees, who have the opportunity to appeal against it. Once NICE issues its final guidance on a technology, it replaces local recommendations across the country.


1. NICE draft guidance. Deep vein thrombosis, pulmonary embolism (treatment, secondary prevention) – apixaban [ID726]. National Institute for Health and Care Excellence 2015. Available from

Published on: March 27, 2015

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