Please login or register to print this page.


Journal of the American Heart Association

Clinical Articles, Lead Article

Moderate sleep restriction impairs endothelial function…

Partial sleep restriction were found to cause endothelial dysfunction in healthy individuals, implicating it as a possible mediator of the heightened cardiovascular risk associated with short sleep duration, according to a study published recently in the Journal of the American Heart Association.1

Sixteen healthy volunteers underwent a randomised study of usual sleep versus sleep restriction of two‐thirds normal sleep time for 8 days/8 nights in a hospital‐based clinical research unit. The main outcome was endothelial function measured by flow‐mediated brachial artery vasodilatation (FMD). Those randomised to sleep restriction slept 5.1 hours/night during the experimental period compared with 6.9 hours/night in the control group.

Sleep restriction was associated with significant impairment in FMD (8.6±4.6% during the initial pre‐randomisation acclimation phase versus 5.2±3.4% during the randomised experimental phase, P=0.01) whereas no change was seen in the control group (5.0±3.0 during the acclimation phase versus 6.73±2.9% during the experimental phase, P=0.10) for a between‐groups difference of −4.40% (95% CI −7.00 to −1.81%, P=0.003). No change was seen in non‐flow mediated vasodilatation (NFMD) in either group.

…and sleep duration predicts 10-year cardiovascular risk

5 - Experimental Sleep Restriction Causes Endothelial Dysfunction in Healthy HumansMean‐predicted 10‐year cardiovascular risk is lowest among adults who report sleeping 7 hours per night, and increases with reported sleep above or below this level, according to a study published recently in the Journal of the American Heart Association.2

Data from 7,690 men and non-pregnant women aged 40 to 79 years, who were free of self‐reported heart disease and stroke, and who participated in a National Health and Nutrition Examination Survey from 2005 to 2012 were analysed. Sleep duration was self‐reported. Predicted 10‐year cardiovascular risk was calculated using the pooled cohort equations.

After adjustment for covariates, geometric mean–predicted 10‐year cardiovascular risk was 4.0%, 3.6%, 3.4%, 3.5%, 3.7%, and 3.7% among participants who reported sleeping ≤5, 6, 7, 8, 9, and ≥10 hours per night, respectively (PWald chi‐square<0.001).

The age‐adjusted percentages of predicted cardiovascular risk ≥20% for the 6 intervals of sleep duration were 14.5%, 11.9%, 11.0%, 11.4%, 11.8%, and 16.3% (PWald chi‐square=0.022). After maximal adjustment, however, sleep duration was not significantly associated with cardiovascular risk ≥20% (PWald chi‐square=0.698).


1. Calvin AD, Covassin N, Kremers WK, et al. Experimental sleep restriction causes endothelial dysfunction in healthy humans. J Am Heart Assoc 2014;3:e001143.

2. Ford ES. Habitual sleep duration and predicted 10‐year cardiovascular risk using the pooled cohort risk equations among US adults. J Am Heart Assoc. 2014;3:e001454.

Published on: December 19, 2014

Members Area

Log in or Register now.

 For healthcare professionals only
Angina book sky



Subscribe to our RSS feed


Sign up for our regular email newsletters & be the first to know about fresh articles and site updates.


    None Found


  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association

You are not logged in

You need to be a member to print this page.
Sign up for free membership, or log in.

You are not logged in

You need to be a member to download PDF's.
Sign up for free membership, or log in.