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American Journal of Cardiology

Clinical Articles, Lead Article

AF recurrence unaffected by n-3 PUFAs treatment

In patients with paroxysmal or persistent atrial fibrillation (AF), treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs) does not reduce the recurrence of AF, nor does it affect concentrations of markers for inflammation and oxidative stress, according to a study published online recently by the American Journal of Cardiology.1

Patients with paroxysmal or persistent AF were randomised to n-3 PUFAs (4 g/day; n = 126) or placebo (n=64) in a 2:1 ratio in a prospective, double-blind study. The primary outcome was time to recurrence of AF. Secondary outcomes were changes in biomarkers of inflammation (serum interleukin [IL]-6, IL-8, IL-10, tissue necrosis factor alpha, monocyte chemoattractant protein-1, and vascular endothelial growth factor), N-terminal-pro-brain-type natriuretic peptide, and oxidative stress (urinary F2-isoprostanes).

AF recurred in 74 patients (58.7%) randomised to n-3 PUFAs and in 30 patients (46.9%) who received placebo; time to recurrence of AF did not differ significantly in the two groups (hazard ratio 1.20; 95% confidence interval 0.76 to 1.90, adjusted p = 0.438). Compared with placebo, n-3 PUFAs did not result in clinically meaningful changes in concentrations of inflammatory markers, N-terminal-pro-brain-type natriuretic peptide or F2-isoprostanes.

Effect of Omega-Three Polyunsaturated Fatty Acids on Inflammation, Oxidative Stress, and Recurrence of Atrial Fibrillation - American Journal of Cardiology2


1. Darghosian L, Free M, Li J, et al. Effect of omega-three polyunsaturated fatty acids on inflammation, oxidative stress, and recurrence of atrial fibrillation. Am J Cardiol 2014.

Published on: December 19, 2014

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  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association

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