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Reduction in early stroke risk with statin treatment

In acute symptomatic carotid stenosis, statin pretreatment is associated with reduced stroke risk, supporting the hypothesis that statins started acutely after transient ischemic attack (TIA) symptom onset may also be beneficial to prevent early stroke, according to a study1 published recently in Stroke.

Authors, aiming to determine whether statin pretreatment at TIA onset modified early stroke risk in carotid stenosis, analysed data from 2,770 patients with TIA from 11 centers, 387 with ipsilateral carotid stenosis. ABCD2 score, abnormal diffusion weighted imaging, medication pretreatment, and early stroke were recorded.

In patients with carotid stenosis, 7-day stroke risk was 8.3% compared with 2.7% without stenosis. Among carotid stenosis patients, nonprocedural seven-day stroke risk was 3.8% with statin treatment at TIA onset, compared with 13.2% in those not statin pretreated. Statin pretreatment was associated with reduced stroke risk in patients with carotid stenosis but not nonstenosis patients. On multivariable logistic regression, the association remained after adjustment for ABCD2 score, smoking, antiplatelet treatment, recent TIA, and diffusion weighted imaging hyperintensity (adjusted P for interaction, 0.054).


1. Merwick A, Albers GW, Arsava EM, et al. Reduction in early stroke risk in carotid stenosis with transient ischemic attack associated with statin treatment. Stroke 2013.​STROKEAHA.113.001576

Published on: September 18, 2013

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  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association

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