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hs troponin test may improve MI diagnosis in women

A high-sensitivity (hs) troponin test may help doctors improve the diagnosis and prognosis of patients presenting with symptoms of myocardial infarction (MI), according to results from a study presented at the ESC Congress 2013.1

The study, conducted by researchers at the University of Edinburgh, is evaluating Abbott’s ARCHITECT STAT High Sensitive Troponin-I (hsTnI) test, which received CE Mark in January 2013.

Researchers shared data from the first 1,126 patients of the study presenting with symptoms of a heart attack. Early findings demonstrate that women have lower peak levels of troponin than men, contributing to the under-diagnosis and therefore under-treatment of heart attacks for women.

“Whilst men and women are just as likely to present to the emergency department with chest pain, currently men are twice as likely to be diagnosed with a heart attack. By using the…high sensitive troponin test and different diagnostic thresholds for men and women, the frequency of diagnosis of heart attacks in women increased and was comparable to men,” said co-author Dr Nicholas Mills (University of Edinburgh).

“The findings of our study, when completed, could change the way we diagnose heart attacks in women, potentially reducing inequalities in the treatment and outcomes, and enabling everyone to receive the best care,” he added

When completed in 2016, this study will include more than 25,000 patients across 10 centers in Scotland, making it one of the largest studies to evaluate the impact of high sensitivity troponin tests on patient care. The study was funded by a special project grant from the British Heart Foundation.

The ARCHITECT STAT hsTnI assay is commercially available in several countries in Europe, as well as Canada, Australia, New Zealand, and Brazil and runs on Abbott’s fully automated ARCHITECT family of analysers.

Other developments in high-sensitivity troponin are explored by Dr James Gamble (John Radcliffe Hospital, Oxford) et al, in an article published recently by the British Journal of Cardiology. Available at http://dx.doi.org/10.5837/bjc.2013.026

References

1. Anoop S, Mills, N, Griffiths M, et al. High-sensitivity cardiac troponin and the underdiagnosis of myocardial infarction in women. Study presented at the ESC Congress 2013, September 4, 2013. Full details available at: http://www.escardio.org/congresses/esc-2013/congress-reports/Pages/711-High-STEACS.aspx#.UjhKBWCvCC8

Published on: September 18, 2013

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  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

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