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Egg consumption not linked to CHD/stroke risk

Higher consumption of eggs (up to one egg per day) is not associated with increased risk of coronary heart disease or stroke, according to a study published recently in the British Medical Journal.1

Researchers performed a dose-response meta-analysis of prospective cohort studies with relative risks and 95% confidence intervals of coronary heart disease or stroke for three or more categories of egg consumption.

Data were also drawn from PubMed and Embase prior to June 2012, and the references of relevant original papers and review articles.

Eight articles with 17 reports (nine for coronary heart disease, eight for stroke) were eligible for inclusion in the meta-analysis, giving a total of 3,081,269 person years and 5,847 incident cases for coronary heart disease, and 4,148,095 person years and 7,579 incident cases for stroke.

No evidence of a curve linear association was seen between egg consumption and risk of coronary heart disease or stroke (p = 0.67 and p = 0.27 for non-linearity, respectively). The summary relative risk of coronary heart disease for an increase of one egg consumed per day was 0.99 (p = 0.88 for linear trend) without heterogeneity among studies (p = 0.97, I2=0%).

iStock_000016420857XSmallFor stroke, the combined relative risk for an increase of one egg consumed per day was 0.91 (p = 0.10 for linear trend) without heterogeneity among studies (p = 0.46, I2=0%). In a subgroup analysis of diabetic populations, the relative risk of coronary heart disease comparing the highest with the lowest egg consumption was 1.54 (p = 0.01). In addition, people with higher egg consumption had a 25% (p = 0.04) lower risk of developing haemorrhagic stroke.

The increased risk of coronary heart disease among diabetic patients and reduced risk of haemorrhagic stroke associated with higher egg consumption in subgroup analyses warrant further studies, said the authors.

References

1. Rong Y, Chen Li, Zhu T, et al. Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies. Br Med J 2013;346:e8539. http://dx.doi.org/10.1136/bmj.e8539

Published on: January 25, 2013

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  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

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