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Journal of the American College of Cardiology

Clinical Articles, News & Views

Body fat and lean mass predict CHD mortality

Both lean mass index (LMI) and body fat (BF) predict mortality in patients with stable coronary heart disease (CHD), according to a study1 published recently in the Journal of the American College of Cardiology.

Researchers studied 570 consecutive patients with CHD who were referred to cardiac rehabilitation, stratified as Low (≤25% in men and ≤35% in women) and High (>25% in men and >35% in women) BF and as Low (≤18.9 kg/m2 in men and ≤15.4 kg/m2 in women) and High LMI, and followed over three years for survival.

Mortality was found to be inversely related to LMI. Mortality was highest in the Low BF/Low LMI group (15%), which was significantly higher than in the other three groups, and lowest in the High BF/High LMI group (2.2%), which was significantly lower than in the other three groups. In Cox regression analysis as categoric variables, low LMI and low BF predicted higher mortality, and as continuous variables, high BF and high LMI predicted lower mortality.

“Despite the recognised study limitations,” said the authors, “our findings indicate that both high LMI and high BF are independent predictors of better survival in those with stable CHD, with mortality especially high in the Low BF/Low LMI group and lowest in the High BF/High LMI group. Prospective studies are needed to validate our findings and to determine the optimal body composition in both primary and secondary CHD prevention”.

References

1. Lavie CJ, De Schutter A, Patel DA, Romero-Corral A, Artham SM, Milani RV. Body composition and survival in stable coronary heart disease. JACC 2012. http://dx.doi.org/10.1016/j.jacc.2012.05.037

Published on: October 19, 2012

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