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ARTICLE CONTRIBUTORS

Journal of the American College of Cardiology

Clinical Articles, Lead Article

Genetic factors may play a role in the development of lone AF

A family history of lone AF is associated with substantial risk of lone AF, with the strongest risks associated with young age at onset, multiple affected relatives, and in first-degree relatives, according to a study published recently in the Journal of the American College of Cardiology.1

Danish and Norwegian researchers investigated whether an individual’s risk of developing lone atrial fibrillation (AF) before age 60 years is associated with lone AF in relatives.  Using Danish national registers, a cohort was established of ~4 million persons born between 1950 and 2008, and those with a family history of lone AF (AF without preceding cardiovascular/endocrine diagnoses) were identified. Individuals were followed up until the first diagnosis of lone AF. Poisson regression was used to estimate incidence rate ratios (IRRs).

In ~92 million person-years of follow-up, 9,507 persons were identified as having lone AF. The IRRs for lone AF given an affected first- or second-degree relative were 3.48 and 1.64, respectively. IRRs were higher for men than for women but were not associated with the affected relative’s sex.

IRR for lone AF was 6.24, given at least two first-degree relatives affected with lone AF. The IRR for lone AF in persons aged <40 years given a first-degree relative affected at age <40 years was 5.42, and 8.53 in persons aged <30 years given a first-degree relative affected at age <30 years.

References

1. Øyen N, Ranthe MF, Carstensen L, et al. Familial Aggregation of Lone Atrial Fibrillation in Young Persons.  JACC 2012. http://dx.doi.org/10.1016/j.jacc.2012.03.046

Published on: August 24, 2012

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ENDORSED BY

  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

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