Please login or register to print this page.

ARTICLE CONTRIBUTORS

Journal of the American College of Cardiology

Clinical Articles, News & Views

Post-conditioning reduces infarct size in STEMI patients

Post-conditioning reduces infarct size and oedema in patients with reperfused ST-segment elevation myocardial infarction, according to a study1 published recently in the Journal of the American College of Cardiology.

Fifty patients with STEMI were randomly assigned to either a control or post-conditioned group. Cardiac magnetic resonance imaging was performed within 48 to 72 hours after admission. Using cardiac magnetic resonance imaging, myocardial oedema was measured by T2-weighted (T2W) sequences, and infarct size was determined by late gadolinium enhancement sequences and creatine kinase release.

The post-conditioned and control groups were similar with respect to ischaemia time, the size of the area at risk, and the ejection fraction before percutaneous coronary intervention. As expected, post-conditioning was associated with smaller infarct size and creatine kinase peak serum level.

At reperfusion, the extent of myocardial oedema was significantly reduced in the post-conditioned group as compared with the control group; the relative increase in T2W signal intensity was also significantly lower. This protective effect was confirmed after adjustment for the size of the area at risk.

“Larger clinical trials will be needed to determine if this translates into improved clinical outcomes,” say the authors.

References

1. Thuny F, Lairez O, Roubille F, et al. Post-conditioning reduces infarct size and edema in patients with ST segment elevation myocardial infarction. JACC 2012;59:2175–81. doi:10.1016/j.jacc.2012.03.026

Published on: June 25, 2012

Members Area

Log in or Register now.

SEARCH THE SITE

RSS FEED

Subscribe to our RSS feed
home

GET EXCLUSIVE UPDATES

Sign up for our regular email newsletters & be the first to know about fresh articles and site updates.

RECENT COMMENTS

    None Found

ENDORSED BY

  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

You are not logged in

You need to be a member to print this page.
Sign up for free membership, or log in.

You are not logged in

You need to be a member to download PDF's.
Sign up for free membership, or log in.