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Stem Cells Translational Medicine

Clinical Articles, News & Views

Stem cell cardiopatch aids post-MI health

A new type of stem cell-seeded patch promotes healing after myocardial infarction (MI), according to a study published recently in the journal Stem Cells Translational Medicine.1

In the “cardiopatch” study, conducted by researchers from the Faculty of Medicine of the Geneva University in collaboration with colleagues at the Ecole Polytechnique Federale de Lausanne (EPFL), cardiac-committed mouse embryonic stem cell (mESC) were committed toward the cardiac fate using a protein growth factor called BMP2 and then embedded into a fibrin hydrogel.

The cells were loaded with superparamagnetic iron oxide nanoparticles so they could be tracked using magnetic resonance imaging, which also enabled the researchers to more accurately assess regional and global heart function. The patches were engrafted onto the hearts of laboratory rats that had induced MI.

Six weeks later, the hearts of the animals receiving the mESC-seeded patches showed significant improvement over those receiving patches loaded with iron oxide nanoparticles alone. The patches had degraded, the cells had colonised the infarcted tissue and new blood vessels were forming in the vicinity of the transplanted patch. Improvements reached beyond the part of the heart where the patch had been applied to manifest globally

Marisa Jaconi, PhD, of the Geneva University Department of Pathology and Immunology, one leader of the investigative team, said: “Altogether our data provide evidence that stem-cell based cardiopatches represent a promising therapeutic strategy to achieve efficient cell implantation and improved global and regional cardiac function after myocardial infarction”.

Reference

1 Vallée JP, Hauwel M, Lepetit-Coiffé M, et al. Embryonic stem cell-based cardiopatches improve cardiac function in infarcted rats. Stem Cells Trans Med 2012;1:248–60. doi:10.5966/sctm.2011-0028

Published on: April 18, 2012

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  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

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