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Clinical Articles, News & Views

Rivaroxaban approved for prevention of non-valvular AF

Rivaroxaban (Xarelto®) has become the first once-daily, fixed-dose preventative treatment for UK patients with non-valvular atrial fibrillation (AF) at risk of stroke, without the need for routine coagulation monitoring.

The oral anticoagulant has now been granted approval by the European Commission (EC) for use in the UK across two new indications:

- The prevention of stroke and non-central nervous system (CNS) systemic embolism in adult patients with non-valvular AF and one or more risk factors for stroke including congestive heart failure, hypertension, age over 75 years, diabetes and prior stroke, at a fixed dose of 20 mg once-daily.

- The treatment of deep vein thrombosis (DVT) and prevention of recurrent DVT and pulmonary embolism (PE) following an acute DVT in adults.

“The consequences of blood clots can be overwhelming and their prevention and treatment should rightly be considered a health priority,” said Trudie Lobban MBE, Chief Executive and Founder of Atrial Fibrillation Association. “Thrombosis represents a massive burden on patients and the UK health system. VKA eligible AF patients, especially those with a higher risk profile and with significant co-morbidities, tend to require more frequent INR testing. The additional tests have a significant impact on these patients’ quality of life as well as on NHS resources, so the approval of new therapy alternatives that are easier to manage than traditional treatments are welcome”.

“Antithrombotic medicine is a fast-evolving area in which we are continually improving our understanding of how to combat blood clots,” said Professor Keith Fox, Professor of Cardiology at the University of Edinburgh. “Treatments which act at a key point in the blood-clotting process are now emerging as an important therapy option in both short and long-term clinical settings, and have the potential to help re-shape clinical practice”.

Published on: January 10, 2012

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ENDORSED BY

  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

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