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Clinical Articles, Lead Article

Digoxin dose level monitoring improved

Two new clinical reference materials for digoxin have been developed by LGC, the UK’s National Measurement Institute for chemical and bioanalytical measurement.

The two new reference materials, which closely match the upper and lower levels for digoxin monitoring, are both certified as European Reference Materials (ERM®) and made under accreditation to ISO Guide 34 for the production of reference materials.

The material (ERM®-DA200a Frozen Human Serum – Digoxin, High Level and ERM®-DA201a Frozen Human Serum – Digoxin, Low Level) are intended for use by clinical laboratories for determining digoxin levels in human serum through method validation and performance monitoring of methods, providing a means of measurement traceability.

Gill Holcombe, Head of Reference Material Production at LGC explains: “Assays for determining levels of digoxin in human serum are independently calibrated but without traceability to an accepted high order reference material. This means that concentration values may not be comparable between different methods or hospital laboratories, posing potential risks to patients”.

“LGC’s new reference materials will improve confidence in measurement, helping clinicians to ensure optimum therapeutic effect and minimise the occurrence of adverse events,” he added.

Liquid chromatography tandem mass spectrometry instrumentation is used in conjunction with LGC’s exact matching isotope dilution procedure, to assign reference values to the digoxin in serum reference materials. Credit: Andrew Brookes, www.andrewbrookes.co.uk

Liquid chromatography tandem mass spectrometry instrumentation is used in conjunction with LGC’s exact matching isotope dilution procedure, to assign reference values to the digoxin in serum reference materials. Credit: Andrew Brookes, www.andrewbrookes.co.uk

Published on: January 10, 2012

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