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ERP – CLINICAL CORRELATES, AND HERITABILITY

The electrocardiographic early repolarisation pattern (ERP) is independently associated with several clinical factors, and may have a heritable basis in the general population, according to a study1 published recently in the Journal of the American College of Cardiology.

Researchers analysed data from 3,995 participants of the Framingham Heart Study (FHS), and 5,489 from the Health 2000 Survey (H2K), testing the association between clinical characteristics and ERP, and estimated sibling recurrence risk.

ERP was present in 423 of 9,444 subjects (4.5%) overall.  Several clinical characteristics, including lower systolic blood pressure, higher Sokolow-Lyon voltage, and lower Cornell voltage, were found to be significant predictors of ERP status in age- and sex-adjusted regression models. In H2K, there was a higher ERP prevalence in men, decreasing prevalence with increasing age, and evidence for an age-by-sex interaction (p =  0.048).

In FHS, siblings of individuals with ERP had an ERP prevalence of 11.6%. Siblings of ERP-positive individuals had increased odds of ERP that was attenuated after adjustment for age and sex.

The authors caution that their findings may not translate to individuals of non-European ancestry, especially those of African descent in whom ERP is particularly prevalent.  They assert that their study is valuable due to its uniform adjudication process and large, community-based cohorts, and encourage further research into genetic determinants of the pattern.

References

1 Noseworthy PA, Tikkanen JT, Porthan K, et al.  The Early Repolarization Pattern in the General Population: Clinical Correlates and Heritability.  JACC 2011;57:doi:10.1016/j.jacc.2011.04.003

Published on: July 6, 2011

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  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

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