Please login or register to print this page.

News & Views

TICAGRELOR – HIGHER RISK OF VENTRICULAR PAUSE

Treatment with ticagrelor rather than clopidogrel increases the danger of ventricular pauses in patients with acute coronary syndromes (ACS), according to a study published recently in the Journal of the American College of Cardiology.1

Researchers led by Dr Benjamin Scirica, Brigham and Women’s Hospital, Boston, performed a prospective continuous electrocardiographic (cECG) assessment on a subset of subjects in the Platelet Inhibition and Patient Outcomes (PLATO) study, which compared ticagrelor to clopidogrel.

In a study of more than 2,900 patients admitted with ACS, who had a planned 7-day cECG recording initiated at the time of randomisation and then repeated at day 30, they found that ticagrelor increased the frequency and incidence of predominately asymptomatic ventricular pauses compared with clopidogrel.  Most ventricular pauses, and most of the excess associated with ticagrelor, were due to sinoatrial (SA) node dysfunction, were nocturnal, and occurred during the first week after randomisation during the acute phase of ACS.

Importantly, there was no significant difference in the number of patients with ventricular pauses in the outpatient setting when patients in the two treatment groups were monitored for 6 consecutive days in association with the 1-month visit.  Furthermore, there were no differences between ticagrelor and clopidogrel in terms of the incidence of clinically reported bradycardic events, either during the cECG assessment period or during 6 to 12 months of clinical follow-up.

References

1 Scirica BM, Cannon CP, Emanuelsson H, et al.  The Incidence of Bradyarrhythmias and Clinical Bradyarrhythmic Events in Patients With Acute Coronary Syndromes Treated With Ticagrelor or Clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) Trial: Results of the Continuous Electrocardiographic Assessment Substudy.  J Am Coll Cardiol 2011:57;1908-16.

Published on: May 6, 2011

Members Area

Log in or Register now.

SEARCH THE SITE

RSS FEED

Subscribe to our RSS feed
home

GET EXCLUSIVE UPDATES

Sign up for our regular email newsletters & be the first to know about fresh articles and site updates.

RECENT COMMENTS

    None Found

ENDORSED BY

  • ArrhythmiaAlliance
  • Stars
  • Anticoagulation Europe
  • Atrial Fibrillation Association
 

You are not logged in

You need to be a member to print this page.
Sign up for free membership, or log in.

You are not logged in

You need to be a member to download PDF's.
Sign up for free membership, or log in.